SDS-PAGE gel of recombinant human Profilin 4 PFN4 protein under reducing conditions

Human Profilin 4/PFN4 protein (Recombinant) (His-Tag) (STJP016650)

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STJP016650
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Short Description :Recombinant-Human Profilin 4/PFN4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:PFN4
Gene ID:375189
Uniprot ID:PROF4_HUMAN
Accession Number:NP_955378
Immunogen:Human
Immunogen Region:1-129aa
Immunogen Sequence: MSHLQSLLLD TLLGTKHVDS AALIKIQERS LCVASPGFNV TPSDVRTLVN GFAKNPLQAR REGLYFKGKD YRCVRADEYS LYAKNENTGV VVVKTHLYLL VATYTEGMYP SICVEATESL GDYLRKKGS
Tissue Specificity Expressed in testis, in germ cells in seminiferous tubules (at protein level). Prominently expressed in pachytene/diplotene stage spematocytes.
Function Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis. Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro.
Protein Name Profilin-4
Profilin Iv
Database Links
Cellular Localisation Cytoplasm
In Round Spermatids
Mainly Observed In The Acroplaxome
During The Progression Of Spermiogenesis
Relocalizes To The Developing Manchette Of Spermatids Step 8 (S8)
Coinciding With The Initiation Of Manchette Disassembly In Spermatids S14
Seen In The Cytoplasm Subjacent To The Disassembling Manchette
Alternative Protein Names Profilin-4 protein
Profilin Iv protein
PFN4 protein

Information sourced from Uniprot.org

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