| Post Translational Modifications | Sumoylated with SUMO1.which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1. Acetylated by lysine acetyltransferase EP300.which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation. |
| Function | Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. |
| Protein Name | Zinc Finger Protein Plag1Pleiomorphic Adenoma Gene 1 Protein |
| Database Links | |
| Cellular Localisation | NucleusStrong Nucleolar Localization When Sumoylation Is Inhibited |
| Alternative Protein Names | Zinc Finger Protein Plag1 proteinPleiomorphic Adenoma Gene 1 Protein proteinPLAG1 protein |
Information sourced from Uniprot.org
