| Function | Pore-forming subunit of a mechanosensitive non-specific cation Piezo channel. Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Piezo channels are homotrimeric three-blade propeller-shaped structure that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. |
| Protein Name | Piezo-Type Mechanosensitive Ion Channel Component 1Membrane Protein Induced By Beta-Amyloid TreatmentMibProtein Fam38a |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCell MembraneCell ProjectionLamellipodium MembraneIn ErythrocytesLocated In The Plasma MembraneAccumulates At The Leading Apical Lamellipodia Of Endothelial Cells In Response To Shear StressColocalizes With F-Actin And Myh9 At The Actomyosin Cortex In Myoblasts |
| Alternative Protein Names | Piezo-Type Mechanosensitive Ion Channel Component 1 proteinMembrane Protein Induced By Beta-Amyloid Treatment proteinMib proteinProtein Fam38a proteinPIEZO1 proteinFAM38A proteinKIAA0233 protein |
Information sourced from Uniprot.org
