| Post Translational Modifications | Undergoes autoproteolytic processing whose extent either directs cells towards survival or apoptotic pathways. Autoproteolytically cleaved into two main fragments PIDD-N and PIDD-C. PIDD-C can be further processed into PIDD-CC, a processing which is enhanced by DNA damage. The cleavage producing PIDD-C is required for translocation of PIDD1 to the nucleus upon DNA damage and activation of NF-kappa-B. PIDD-CC mediates the interaction with CRADD and the cleavage producing PIDD-CC is required for the activation of CASP2. PIDD-N remains associated with PIDD-C and PIDD-CC after cleavage. |
| Function | Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B. |
| Protein Name | P53-Induced Death Domain-Containing Protein 1Leucine-Rich Repeat And Death Domain-Containing Protein Cleaved Into - Pidd-N - Pidd-C - Pidd-Cc |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleusEnriched In The Nucleus Upon Dna Damage |
| Alternative Protein Names | P53-Induced Death Domain-Containing Protein 1 proteinLeucine-Rich Repeat And Death Domain-Containing Protein Cleaved Into - Pidd-N - Pidd-C - Pidd-Cc proteinPIDD1 proteinLRDD proteinPIDD protein |
Information sourced from Uniprot.org
