Human PIDD1 protein (Recombinant) (N-His) (STJP006013)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PIDD1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PIDD1 |
| Gene ID | 55367 |
| Uniprot ID | PIDD1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe694-Arg885 |
Additional Info
| Post Translational Modifications | Undergoes autoproteolytic processing whose extent either directs cells towards survival or apoptotic pathways. Autoproteolytically cleaved into two main fragments PIDD-N and PIDD-C. PIDD-C can be further processed into PIDD-CC, a processing which is enhanced by DNA damage. The cleavage producing PIDD-C is required for translocation of PIDD1 to the nucleus upon DNA damage and activation of NF-kappa-B. PIDD-CC mediates the interaction with CRADD and the cleavage producing PIDD-CC is required for the activation of CASP2. PIDD-N remains associated with PIDD-C and PIDD-CC after cleavage. |
| Function | Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B. |
| Protein Name | P53-Induced Death Domain-Containing Protein 1Leucine-Rich Repeat And Death Domain-Containing Protein Cleaved Into - Pidd-N - Pidd-C - Pidd-Cc |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleusEnriched In The Nucleus Upon Dna Damage |
| Alternative Protein Names | P53-Induced Death Domain-Containing Protein 1 proteinLeucine-Rich Repeat And Death Domain-Containing Protein Cleaved Into - Pidd-N - Pidd-C - Pidd-Cc proteinPIDD1 proteinLRDD proteinPIDD protein |
Information sourced from Uniprot.org