Human PHF2 protein (Recombinant) (N-His) (STJP016314)

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STJP016314
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Short Description :Recombinant-Human PHF2-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:PHF2
Gene ID:5253
Uniprot ID:PHF2_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Gln83-Arg450
Post Translational Modifications Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex.
Function Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
Protein Name Lysine-Specific Demethylase Phf2
Grc5
Phd Finger Protein 2
Database Links Reactome: R-HSA-3214842
Cellular Localisation Nucleus
Nucleolus
Chromosome
Centromere
Kinetochore
Alternative Protein Names Lysine-Specific Demethylase Phf2 protein
Grc5 protein
Phd Finger Protein 2 protein
PHF2 protein
CENP-35 protein
KIAA0662 protein

Information sourced from Uniprot.org

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