| Post Translational Modifications | Cleaved by ELANE.proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production.granulin-3 and granulin-4 are resistant to ELANE. Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome. |
| Function | Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity. Granulin-4: Promotes proliferation of the epithelial cell line A431 in culture. Granulin-3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Granulin-7: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. |
| Protein Name | ProgranulinPgrnAcrograninEpithelin PrecursorGlycoprotein Of 88 KdaGp88Glycoprotein 88Granulin PrecursorPc Cell-Derived Growth FactorPcdgfProepithelinPepi Cleaved Into - Paragranulin - Granulin-1Granulin G - Granulin-2Granulin F - Granulin-3Epithelin-2Granulin B - Granulin-4Epithelin-1Granulin A - Granulin-5Granulin C - Granulin-6Granulin D - Granulin-7Granulin E |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedLysosomeEndocytosed By Sort1 And Delivred To LysosomesTargeted To Lysosome By Psap Via M6pr And Lrp1In Both Biosynthetic And Endocytic PathwaysCo-Localized With Gba1 In The Intracellular Trafficking Compartments Until To Lysosome |
| Alternative Antibody Pair Names | Progranulin antibody pairPgrn antibody pairAcrogranin antibody pairEpithelin Precursor antibody pairGlycoprotein Of 88 Kda antibody pairGp88 antibody pairGlycoprotein 88 antibody pairGranulin Precursor antibody pairPc Cell-Derived Growth Factor antibody pairPcdgf antibody pairProepithelin antibody pairPepi Cleaved Into - Paragranulin - Granulin-1 antibody pairGranulin G - Granulin-2 antibody pairGranulin F - Granulin-3 antibody pairEpithelin-2 antibody pairGranulin B - Granulin-4 antibody pairEpithelin-1 antibody pairGranulin A - Granulin-5 antibody pairGranulin C - Granulin-6 antibody pairGranulin D - Granulin-7 antibody pairGranulin E antibody pairGRN antibody pair |
Information sourced from Uniprot.org
