Human PEX19 protein (Recombinant) (His-Tag) (STJP017328)

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STJP017328
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PEX19-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: PEX19
Gene ID: 5824
Uniprot ID: PEX19_HUMAN
Immunogen Region: 1-296aa
Accession Number: NP_002848.1
Immunogen: Human
Immunogen Sequence: MAAAEEGCSV GAEADRELEE LLESALDDFD KAKPSPAPPS TTTAPDASGP QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDMT SQQEFTSCLK ETLSGLAKNA TDLQNSSMSE EELTKAMEGL GMDEGDGEGN ILPIMQSIMQ NLLSKDVLYP SLKEITEKYP EWLQSH
Tissue Specificity Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.
Function Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Protein Name Peroxisomal Biogenesis Factor 19
33 Kda Housekeeping Protein
Peroxin-19
Peroxisomal Farnesylated Protein
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-9603798
Cellular Localisation Cytoplasm
Peroxisome Membrane
Lipid-Anchor
Cytoplasmic Side
Mainly Cytoplasmic
Some Fraction Membrane-Associated To The Outer Surface Of Peroxisomes
Alternative Protein Names Peroxisomal Biogenesis Factor 19 protein
33 Kda Housekeeping Protein protein
Peroxin-19 protein
Peroxisomal Farnesylated Protein protein
PEX19 protein
HK33 protein
PXF protein
OK protein
SW-cl.22 protein

Information sourced from Uniprot.org

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