Human Peroxiredoxin 3/PRDX3 protein (Recombinant) (No-Tag) (STJP016467)

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STJP016467
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Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Peroxiredoxin 3/PRDX3-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Specific activity is >2, 000pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for 1minute.
Gene Symbol: PRDX3
Gene ID: 10935
Uniprot ID: PRDX3_HUMAN
Immunogen Region: 63-256aa
Accession Number: NP_006784
Immunogen: Human
Immunogen Sequence: MPAVTQHAPY FKGTAVVNGE FKDLSLDDFK GKYLVLFFYP LDFTFVCPTE IVAFSDKANE FHDVNCEVVA VSVDSHFSHL AWINTPRKNG GLGHMNIALL SDLTKQISRD YGVLLEGSGL ALRGLFIIDP NGVIKHLSVN DLPVGRSVEE TLRLVKAFQY VETHGEVCPA NWTPDSPTIK PSPAASKEYF QKVNQ
Post Translational Modifications Phosphorylated by LRRK2.phosphorylation reduces perodixase activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. S-palmitoylated.
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength.
Protein Name Thioredoxin-Dependent Peroxide Reductase - Mitochondrial
Antioxidant Protein 1
Aop-1
Hbc189
Peroxiredoxin Iii
Prx-Iii
Peroxiredoxin-3
Protein Mer5 Homolog
Thioredoxin-Dependent Peroxiredoxin 3
Database Links Reactome: R-HSA-3299685
Cellular Localisation Mitochondrion
Cytoplasm
Early Endosome
Localizes To Early Endosomes In A Rps6kc1-Dependent Manner
Alternative Protein Names Thioredoxin-Dependent Peroxide Reductase - Mitochondrial protein
Antioxidant Protein 1 protein
Aop-1 protein
Hbc189 protein
Peroxiredoxin Iii protein
Prx-Iii protein
Peroxiredoxin-3 protein
Protein Mer5 Homolog protein
Thioredoxin-Dependent Peroxiredoxin 3 protein
PRDX3 protein
AOP1 protein

Information sourced from Uniprot.org

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