| Post Translational Modifications | Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol. |
| Function | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer.the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-CTTAATTG-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
| Protein Name | Pancreas/Duodenum Homeobox Protein 1Pdx-1Glucose-Sensitive FactorGsfInsulin Promoter Factor 1Ipf-1Insulin Upstream Factor 1Iuf-1Islet/Duodenum Homeobox-1Idx-1Somatostatin-Transactivating Factor 1Stf-1 |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-210747 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Protein Names | Pancreas/Duodenum Homeobox Protein 1 proteinPdx-1 proteinGlucose-Sensitive Factor proteinGsf proteinInsulin Promoter Factor 1 proteinIpf-1 proteinInsulin Upstream Factor 1 proteinIuf-1 proteinIslet/Duodenum Homeobox-1 proteinIdx-1 proteinSomatostatin-Transactivating Factor 1 proteinStf-1 proteinPDX1 proteinIPF1 proteinSTF1 protein |
Information sourced from Uniprot.org
