Function | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXXKRR consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. |
Protein Name | Proprotein Convertase Subtilisin/Kexin Type 5Proprotein Convertase 5Pc5Proprotein Convertase 6Pc6Hpc6Subtilisin/Kexin-Like Protease Pc5 |
Database Links | Reactome: R-HSA-167060Reactome: R-HSA-8963889 |
Cellular Localisation | Isoform Pc6a: SecretedSecreted Through The Regulated Secretory PathwayIsoform Pc6b: Endomembrane SystemSingle-Pass Type I Membrane ProteinType I Membrane Protein Localized To A Paranuclear Post-Golgi Network Compartment In Communication With Early Endosomes |
Alternative Protein Names | Proprotein Convertase Subtilisin/Kexin Type 5 proteinProprotein Convertase 5 proteinPc5 proteinProprotein Convertase 6 proteinPc6 proteinHpc6 proteinSubtilisin/Kexin-Like Protease Pc5 proteinPCSK5 proteinPC5 proteinPC6 protein |
Information sourced from Uniprot.org