Human PCSK5 protein (Recombinant) (N-His) (STJP005792)

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STJP005792
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PCSK5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PCSK5
Gene ID: 5125
Uniprot ID: PCSK5_HUMAN
Immunogen Region: Asp115-Met454
Immunogen: Homo sapiens (Human)
Function Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXXKRR consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
Protein Name Proprotein Convertase Subtilisin/Kexin Type 5
Proprotein Convertase 5
Pc5
Proprotein Convertase 6
Pc6
Hpc6
Subtilisin/Kexin-Like Protease Pc5
Database Links Reactome: R-HSA-167060
Reactome: R-HSA-8963889
Cellular Localisation Isoform Pc6a: Secreted
Secreted Through The Regulated Secretory Pathway
Isoform Pc6b: Endomembrane System
Single-Pass Type I Membrane Protein
Type I Membrane Protein Localized To A Paranuclear Post-Golgi Network Compartment In Communication With Early Endosomes
Alternative Protein Names Proprotein Convertase Subtilisin/Kexin Type 5 protein
Proprotein Convertase 5 protein
Pc5 protein
Proprotein Convertase 6 protein
Pc6 protein
Hpc6 protein
Subtilisin/Kexin-Like Protease Pc5 protein
PCSK5 protein
PC5 protein
PC6 protein

Information sourced from Uniprot.org

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