Human PARG protein (Recombinant) (N-His) (STJP005653)

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STJP005653
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PARG-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PARG
Gene ID: 670/8505
Uniprot ID: PARG_HUMAN
Immunogen Region: Ser448-Thr976
Immunogen: Homo sapiens (Human)
Function Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.
Protein Name Poly(Adp-Ribose Glycohydrolase
Database Links Reactome: R-HSA-110362
Cellular Localisation Isoform 1: Nucleus
Colocalizes With Pcna At Replication Foci
Relocalizes To The Cytoplasm In Response To Dna Damage
Isoform 2: Cytoplasm
Translocates To The Nucleus In Response To Dna Damage
Isoform 3: Cytoplasm
Isoform 4: Cytoplasm
Mitochondrion
Isoform 5: Mitochondrion Matrix
Alternative Protein Names Poly(Adp-Ribose Glycohydrolase protein
PARG protein

Information sourced from Uniprot.org

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