Human DISC1 protein (Recombinant) (N-His) (STJP006077)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human DISC1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | DISC1 |
| Gene ID | 27185 |
| Uniprot ID | DISC1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser102-Cys261 |
Additional Info
| Post Translational Modifications | Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. |
| Function | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation. |
| Protein Name | Disrupted In Schizophrenia 1 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMitochondrionMicrotubule Organizing CenterCentrosomePostsynaptic DensityColocalizes With Ndel1 In The Perinuclear Region And The CentrosomeLocalizes To Punctate Cytoplasmic Foci Which Overlap In Part With MitochondriaColocalizes With Pcnt At The Centrosome |
| Alternative Protein Names | Disrupted In Schizophrenia 1 Protein proteinDISC1 proteinKIAA0457 protein |
Information sourced from Uniprot.org