| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | PTH |
| Gene ID: | 5741 |
| Uniprot ID: | PTHY_HUMAN |
| Immunogen Region: | Ser32-Gln115 |
| Immunogen: | Recombinant Human Parathormone/PTH Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser32-Gln115) of human Parathormone/PTH (Accession #NP_000306.1) fused with no additional amino acid. |
| Immunogen Sequence: | GDEDPQIAAHVVSEANSNAA SVLQWAKKGYYTMKSNLVML ENGKQLTVKREGLYYVYTQV TFCSNREPSSQRPFIVGLWL KPSSGSERILLKAANTHSSS QLCEQQSVHLGGVFELQAGA SVFVNVTEASQVIHRVGFSS FGLLKL |
| Function | Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates 1-14C-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. |
| Protein Name | Parathyroid HormonePthParathormoneParathyrin |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Parathyroid Hormone proteinPth proteinParathormone proteinParathyrin proteinPTH protein |
Information sourced from Uniprot.org
