| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. Plays indirectly an important role in skeletogenesis during postnatal growth. |
| Protein Name | Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2Paps Synthase 2Papss 2Sulfurylase Kinase 2Sk 2Sk2 Includes - Sulfate AdenylyltransferaseAtp-SulfurylaseSulfate Adenylate TransferaseSat - Adenylyl-Sulfate Kinase3'-Phosphoadenosine-5'-Phosphosulfate SynthaseAps KinaseAdenosine-5'-Phosphosulfate 3'-PhosphotransferaseAdenylylsulfate 3'-Phosphotransferase |
| Database Links | Reactome: R-HSA-174362Reactome: R-HSA-2408550Reactome: R-HSA-3560796 |
| Cellular Localisation | |
| Alternative Protein Names | Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 proteinPaps Synthase 2 proteinPapss 2 proteinSulfurylase Kinase 2 proteinSk 2 proteinSk2 Includes - Sulfate Adenylyltransferase proteinAtp-Sulfurylase proteinSulfate Adenylate Transferase proteinSat - Adenylyl-Sulfate Kinase protein3'-Phosphoadenosine-5'-Phosphosulfate Synthase proteinAps Kinase proteinAdenosine-5'-Phosphosulfate 3'-Phosphotransferase proteinAdenylylsulfate 3'-Phosphotransferase proteinPAPSS2 proteinATPSK2 protein |
Information sourced from Uniprot.org
