| Function | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner. Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR. |
| Protein Name | Platelet-Activating Factor Acetylhydrolase Ib Subunit BetaLissencephaly-1 ProteinLis-1Paf Acetylhydrolase 45 Kda SubunitPaf-Ah 45 Kda SubunitPaf-Ah AlphaPafah Alpha |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5663220Reactome: R-HSA-6811436Reactome: R-HSA-68877Reactome: R-HSA-8854518Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleNucleus MembraneRedistributes To Axons During Neuronal DevelopmentAlso Localizes To The Microtubules Of The Manchette In Elongating Spermatids And To The Meiotic Spindle In SpermatocytesLocalizes To The Plus End Of Microtubules And To The CentrosomeMay Localize To The Nuclear Membrane |
| Alternative Protein Names | Platelet-Activating Factor Acetylhydrolase Ib Subunit Beta proteinLissencephaly-1 Protein proteinLis-1 proteinPaf Acetylhydrolase 45 Kda Subunit proteinPaf-Ah 45 Kda Subunit proteinPaf-Ah Alpha proteinPafah Alpha proteinPAFAH1B1 proteinLIS1 proteinMDCR proteinMDS proteinPAFAHA protein |
Information sourced from Uniprot.org
