Human PA28 gamma/PSME3 protein (Recombinant) (His-Tag) (STJP017426)

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STJP017426
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PA28 gamma/PSME3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 40% Glycerol, 200mM NaCl
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: PSME3
Gene ID: 10197
Uniprot ID: PSME3_HUMAN
Immunogen Region: 1-254aa
Accession Number: NP_005780.2
Immunogen: Human
Immunogen Sequence: MASLLKVDQE VKLKVDSFRE RITSEAEDLV ANFFPKKLLE LDSFLKEPIL NIHDLTQIHS DMNLPVPDPI LLTNSHDGLD GPTYKKRRLD ECEEAFQGTK VFVMPNGMLK SNQQLVDIIE KVKPEIRLLI EKCNTVKMWV QLLIPRIEDG NNFGVSIQEE TVAELRTVES EAASYLDQIS RYYITRAKLV SKIAKYPHVE DYRRTV
Post Translational Modifications Phosphorylated by MAP3K3. Phosphorylation at Ser-247 promotes its association with CCAR2. Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1.
Function Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.
Protein Name Proteasome Activator Complex Subunit 3
11s Regulator Complex Subunit Gamma
Reg-Gamma
Activator Of Multicatalytic Protease Subunit 3
Ki Nuclear Autoantigen
Proteasome Activator 28 Subunit Gamma
Pa28g
Pa28gamma
Database Links Reactome: R-HSA-9907900
Cellular Localisation Nucleus
Cytoplasm
Localizes To The Cytoplasm During Mitosis Following Nuclear Envelope Breakdown At This Distinct Stage Of The Cell Cycle Which Allows Its Interaction With Map3k3 Kinase
Alternative Protein Names Proteasome Activator Complex Subunit 3 protein
11s Regulator Complex Subunit Gamma protein
Reg-Gamma protein
Activator Of Multicatalytic Protease Subunit 3 protein
Ki Nuclear Autoantigen protein
Proteasome Activator 28 Subunit Gamma protein
Pa28g protein
Pa28gamma protein
PSME3 protein

Information sourced from Uniprot.org

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