| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human GPNMB Protein at 1 Mu g/mL (100 Mu L/well) can bind GPNMB Rabbit pAb with a linear range of 0.976-116.5 ng/mL. |
| Gene Symbol: | GPNMB |
| Gene ID: | 10457 |
| Uniprot ID: | GPNMB_HUMAN |
| Immunogen Region: | Met1-Pro474 |
| Immunogen: | Recombinant Human Osteoactivin/GPNMB Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Pro474) of human Osteoactivin/GPNMB (Accession #NP_002501.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | MECLYYFLGFLLLAARLPLD AAKRFHDVLGNERPSAYMRE HNQLNGWSSDENDWNEKLYP VWKRGDMRWKNSWKGGRVQA VLTSDSPALVGSNITFAVNL IFPRCQKEDANGNIVYEKNC RNEAGLSADPYVYNWTAWSE DSDGENGTGQSHHNVFPDGK PFPHHPGWRRWNFIYVFHTL GQYFQKLGRCSVRVSVNTAN VTLGPQLMEVTVYRRHGRAY VPIAQVKDVYVVTDQIPVF |
| Function | Could be a melanogenic enzyme. |
| Protein Name | Transmembrane Glycoprotein NmbHematopoietic Growth Factor Inducible Neurokinin-1 Type |
| Database Links | Reactome: R-HSA-8857538 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMelanosome MembraneEarly Endosome MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Protein Names | Transmembrane Glycoprotein Nmb proteinHematopoietic Growth Factor Inducible Neurokinin-1 Type proteinGPNMB proteinHGFIN proteinNMB proteinUNQ1725 proteinPRO9925 protein |
Information sourced from Uniprot.org
