Human Ornithine Carbamoyltransferase/OTC protein (Recombinant) (His-Tag) (STJP017596)

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STJP017596
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Ornithine Carbamoyltransferase/OTC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM MES buffer (pH 6.0) containing 2mM DTT, 10% Glycerol, 100mM NaCl
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: OTC
Gene ID: 5009
Uniprot ID: OTC_HUMAN
Immunogen Region: 33-354aa
Accession Number: NP_000522.3
Immunogen: Human
Immunogen Sequence: NKVQL KGRDLLTLKN FTGEEIKYML WLSADLKFRI KQKGEYLPLL QGKSLGMIFE KRSTRTRLST ETGFALLGGH PCFLTTQDIH LGVNESLTDT ARVLSSMADA VLARVYKQSD LDTLAKEASI PIINGLSDLY HPIQILADYL TLQEHYSSLK GLTLSWIGDG NNILHSIMMS AAKFGMHLQA ATPKGYEPDA SVTKLA
Tissue Specificity Mainly expressed in liver and intestinal mucosa.
Post Translational Modifications Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.
Function Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
Protein Name Ornithine Transcarbamylase - Mitochondrial
Otcase
Ornithine Carbamoyltransferase - Mitochondrial
Database Links Reactome: R-HSA-1268020
Reactome: R-HSA-70635
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Ornithine Transcarbamylase - Mitochondrial protein
Otcase protein
Ornithine Carbamoyltransferase - Mitochondrial protein
OTC protein

Information sourced from Uniprot.org

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