Human Ornithine Carbamoyltransferase/OTC protein (Recombinant) (His-Tag) (STJP017596)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Ornithine Carbamoyltransferase/OTC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM MES buffer (pH 6.0) containing 2mM DTT, 10% Glycerol, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OTC |
| Gene ID | 5009 |
| Uniprot ID | OTC_HUMAN |
| Accession Number | NP_000522.3 |
| Immunogen | Human |
| Immunogen Region | 33-354aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Mainly expressed in liver and intestinal mucosa. |
| Post Translational Modifications | Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. |
| Function | Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. |
| Protein Name | Ornithine Transcarbamylase - MitochondrialOtcaseOrnithine Carbamoyltransferase - Mitochondrial |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-70635 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Ornithine Transcarbamylase - Mitochondrial proteinOtcase proteinOrnithine Carbamoyltransferase - Mitochondrial proteinOTC protein |
Information sourced from Uniprot.org