Human O-fucosyltransferase 1/POFUT1 protein (Recombinant) (His-Tag) (STJP018020)

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STJP018020
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Short Description :Recombinant-Human O-fucosyltransferase 1/POFUT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:POFUT1
Gene ID:23509
Uniprot ID:OFUT1_HUMAN
Accession Number:NP_056167
Immunogen:Human
Immunogen Region:27-388aa
Immunogen Sequence:GSWDPAG YLLYCPCMGR FGNQADHFLG SLAFAKLLNR TLAVPPWIEY QHHKPPFTNL HVSYQKYFKL EPLQAYHRVI SLEDFMEKLA PTHWPPEKRV AYCFEVAAQR SPDKKTCPMK EGNPFGPFWD QFHVSFNKSE LFTGISFSAS YREQWSQRFS PKEHPVLALP GAPAQFPVLE EHRPLQKYMV WSDEMVKTGE AQIHAH
Tissue Specificity Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post Translational Modifications N-glycosylated.
Function Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-S/T-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).
Protein Name Gdp-Fucose Protein O-Fucosyltransferase 1
Peptide-O-Fucosyltransferase 1
O-Fuct-1
Database Links Reactome: R-HSA-1912399
Cellular Localisation Endoplasmic Reticulum
Alternative Protein Names Gdp-Fucose Protein O-Fucosyltransferase 1 protein
Peptide-O-Fucosyltransferase 1 protein
O-Fuct-1 protein
POFUT1 protein
FUT12 protein
KIAA0180 protein

Information sourced from Uniprot.org

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