SDS-PAGE gel of recombinant human NUDT5 protein under reducing conditions Coomassie blue stain

Human NUDT5 protein (Recombinant) (His-Tag) (STJP016773)

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STJP016773
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Short Description :Recombinant-Human NUDT5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 0.1M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:NUDT5
Gene ID:11164
Uniprot ID:NUDT5_HUMAN
Accession Number:NP_054861
Immunogen:Human
Immunogen Region:1-219aa
Immunogen Sequence: MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ RLDALVAEEH LTVDARVYSY ALALKH
Tissue Specificity Widely expressed. Most abundant in liver.
Post Translational Modifications Phosphorylation at Thr-45 is required for homodimer stability.dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity.
Function Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Protein Name Adp-Sugar Pyrophosphatase
8-Oxo-Dgdp Phosphatase
Nuclear Atp-Synthesis Protein Nudix5
Nucleoside Diphosphate-Linked Moiety X Motif 5
Nudix Motif 5
Hnudt5
Ysa1h
Database Links Reactome: R-HSA-2393930
Cellular Localisation Nucleus
Alternative Protein Names Adp-Sugar Pyrophosphatase protein
8-Oxo-Dgdp Phosphatase protein
Nuclear Atp-Synthesis Protein Nudix5 protein
Nucleoside Diphosphate-Linked Moiety X Motif 5 protein
Nudix Motif 5 protein
Hnudt5 protein
Ysa1h protein
NUDT5 protein
NUDIX5 protein
HSPC115 protein

Information sourced from Uniprot.org

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