Human NUDT5 protein (Recombinant) (His-Tag) (STJP016773)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NUDT5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NUDT5 |
| Gene ID | 11164 |
| Uniprot ID | NUDT5_HUMAN |
| Accession Number | NP_054861 |
| Immunogen | Human |
| Immunogen Region | 1-219aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed. Most abundant in liver. |
| Post Translational Modifications | Phosphorylation at Thr-45 is required for homodimer stability.dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity. |
| Function | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. |
| Protein Name | Adp-Sugar Pyrophosphatase8-Oxo-Dgdp PhosphataseNuclear Atp-Synthesis Protein Nudix5Nucleoside Diphosphate-Linked Moiety X Motif 5Nudix Motif 5Hnudt5Ysa1h |
| Database Links | Reactome: R-HSA-2393930 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Adp-Sugar Pyrophosphatase protein8-Oxo-Dgdp Phosphatase proteinNuclear Atp-Synthesis Protein Nudix5 proteinNucleoside Diphosphate-Linked Moiety X Motif 5 proteinNudix Motif 5 proteinHnudt5 proteinYsa1h proteinNUDT5 proteinNUDIX5 proteinHSPC115 protein |
Information sourced from Uniprot.org