Human NUDC protein (Recombinant) (His-Tag) (STJP019285)

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STJP019285
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Short Description :Recombinant-Human NUDC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:NUDC
Gene ID:10726
Uniprot ID:NUDC_HUMAN
Accession Number:AAH02399
Immunogen:Human
Immunogen Region:1-331aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGGEQEE ERFDGMLLAM AQQHEGGVQE LVNTFFSFLR RKTDFFIGGE EGMAEKLITQ TFSHHNQLAQ KTRREKRARQ EAERREKAER AARLAKEAKS ETSGPQIKEL TDEEAERLQL EIDQKKDAEN HEAQLKNGSL DSPGKQDTEE DEEEDEKDKG KLKPNLGNGA DLPNYRWTQT LSELDLAVPF CVNFRLKGKD MVVDIQRR
Tissue Specificity Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
Post Translational Modifications Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.
Function Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Protein Name Nuclear Migration Protein Nudc
Nuclear Distribution Protein C Homolog
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Reactome: R-HSA-9696270
Cellular Localisation Cytoplasm
Cytoskeleton
Nucleus
Spindle
Midbody
In A Filamentous Pattern Adjacent To The Nucleus Of Migrating Cerebellar Granule Cells
Colocalizes With Tubulin And Dynein And With The Microtubule Organizing Center
Distributed Throughout The Cytoplasm Of Non-Migrating Cells
A Small Proportion Is Nuclear
In A Punctate Pattern
Localizes To The Mitotic Spindle In A Eml4-Dependent Manner
Alternative Protein Names Nuclear Migration Protein Nudc protein
Nuclear Distribution Protein C Homolog protein
NUDC protein

Information sourced from Uniprot.org

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