Human NR3C2 protein (Recombinant) (N-GST) (STJP003829)

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STJP003829
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NR3C2-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NR3C2
Gene ID: 4306
Uniprot ID: MCR_HUMAN
Immunogen Region: Gly789-Lys984
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated.
Function Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Protein Name Mineralocorticoid Receptor
Mr
Nuclear Receptor Subfamily 3 Group C Member 2
Database Links Reactome: R-HSA-3371497
Reactome: R-HSA-383280
Reactome: R-HSA-4090294
Cellular Localisation Cytoplasm
Nucleus
Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic And Nuclear In The Absence Of Ligand
Nuclear After Ligand-Binding
When Bound To Hsd11b2
It Is Found Associated With The Endoplasmic Reticulum Membrane
Alternative Protein Names Mineralocorticoid Receptor protein
Mr protein
Nuclear Receptor Subfamily 3 Group C Member 2 protein
NR3C2 protein
MCR protein
MLR protein

Information sourced from Uniprot.org

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