SDS-PAGE gel of recombinant human NIPSNAP1 protein under reducing conditions Coomassie blue stain

Human NIPSNAP1 protein (Recombinant) (His-Tag) (STJP018500)

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STJP018500
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Short Description :Recombinant-Human NIPSNAP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:NIPSNAP1
Gene ID:8508
Uniprot ID:NIPS1_HUMAN
Accession Number:NP_003625
Immunogen:Human
Immunogen Region:1-284aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAPRLCS ISVTARRLLG GPGPRAGDVA SAAAARFYSK DNEGSWFRSL FVHKVDPRKD AHSTLLSKKE TSNLYKIQFH NVKPEYLDAY NSLTEAVLPK LHLDEDYPCS LVGNWNTWYG EQDQAVHLWR FSGGYPALMD CMNKLKNNKE YLEFRRERSQ MLLSRRNQLL LEFSFWNEPQ PRMGPNIYEL RTYKLKPGTM IEWGNNWA
Tissue Specificity Ubiquitous. Highest expression in liver.
Post Translational Modifications In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1.
Function Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria. Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2).
Protein Name Protein Nipsnap Homolog 1
Nipsnap1
Database Links
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Protein Nipsnap Homolog 1 protein
Nipsnap1 protein
NIPSNAP1 protein

Information sourced from Uniprot.org

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