Human NIPSNAP1 protein (Recombinant) (His-Tag) (STJP018500)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NIPSNAP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NIPSNAP1 |
| Gene ID | 8508 |
| Uniprot ID | NIPS1_HUMAN |
| Accession Number | NP_003625 |
| Immunogen | Human |
| Immunogen Region | 1-284aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAPRLCS ISVTARRLLG GPGPRAGDVA SAAAARFYSK DNEGSWFRSL FVHKVDPRKD AHSTLLSKKE TSNLYKIQFH NVKPEYLDAY NSLTEAVLPK LHLDEDYPCS LVGNWNTWYG EQDQAVHLWR FSGGYPALMD CMNKLKNNKE YLEFRRERSQ MLLSRRNQLL LEFSFWNEPQ PRMGPNIYEL RTYKLKPGTM IEWGNNWA |
Additional Info
| Tissue Specificity | Ubiquitous. Highest expression in liver. |
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria. Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2). |
| Protein Name | Protein Nipsnap Homolog 1Nipsnap1 |
| Database Links | |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Protein Nipsnap Homolog 1 proteinNipsnap1 proteinNIPSNAP1 protein |
Information sourced from Uniprot.org