| Function | Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). |
| Protein Name | Nf-Kappa-B Inhibitor ZetaI-Kappa-B-ZetaIkb-ZetaIkappabzetaIl-1 Inducible Nuclear Ankyrin-Repeat ProteinInapMolecule Possessing Ankyrin Repeats Induced By LipopolysaccharideMail |
| Database Links | |
| Cellular Localisation | NucleusAggregated In Dot-Like StructuresColocalizes With Ncor2 |
| Alternative Protein Names | Nf-Kappa-B Inhibitor Zeta proteinI-Kappa-B-Zeta proteinIkb-Zeta proteinIkappabzeta proteinIl-1 Inducible Nuclear Ankyrin-Repeat Protein proteinInap proteinMolecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide proteinMail proteinNFKBIZ proteinIKBZ proteinINAP proteinMAIL protein |
Information sourced from Uniprot.org
