| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. |
| Protein Name | Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13Cell Death Regulatory Protein Grim-19Complex I-B16.6Ci-B16.6Gene Associated With Retinoic And Interferon-Induced Mortality 19 ProteinGrim-19Gene Associated With Retinoic And Ifn-Induced Mortality 19 ProteinNadh-Ubiquinone Oxidoreductase B16.6 Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-6799198Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMatrix SideNucleusLocalizes Mainly In The MitochondrionMay Be Translocated Into The Nucleus Upon Ifn/Ra Treatment |
| Alternative Protein Names | Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13 proteinCell Death Regulatory Protein Grim-19 proteinComplex I-B16.6 proteinCi-B16.6 proteinGene Associated With Retinoic And Interferon-Induced Mortality 19 Protein proteinGrim-19 proteinGene Associated With Retinoic And Ifn-Induced Mortality 19 Protein proteinNadh-Ubiquinone Oxidoreductase B16.6 Subunit proteinNDUFA13 proteinGRIM19 proteinCDA016 proteinCGI-39 protein |
Information sourced from Uniprot.org
