Human ROBO1 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007610)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ROBO1-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ROBO1 |
| Gene ID | 6091 |
| Uniprot ID | ROBO1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg69-Ala166 |
Additional Info
| Post Translational Modifications | Ubiquitinated. May be deubiquitinated by USP33. |
| Function | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B.inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development. |
| Protein Name | Roundabout Homolog 1Deleted In U Twenty TwentyH-Robo-1 |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376176Reactome: R-HSA-428540Reactome: R-HSA-428542Reactome: R-HSA-428543Reactome: R-HSA-428890Reactome: R-HSA-8985586Reactome: R-HSA-8985801Reactome: R-HSA-9010553 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneSingle-Pass Membrane ProteinDetected At Growth Cones In Thalamus NeuronsPrrg4 Prevents Cell Surface Location And Both Colocalize In The Endoplasmic Reticulum/Golgi Adjacent To The Cell Nucleus |
| Alternative Protein Names | Roundabout Homolog 1 proteinDeleted In U Twenty Twenty proteinH-Robo-1 proteinROBO1 proteinDUTT1 protein |
Information sourced from Uniprot.org