Human NCE2/UBE2F protein (Recombinant) (His-Tag) (STJP017716)

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STJP017716
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Short Description :Recombinant-Human NCE2/UBE2F-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 30% Glycerol, 1mM DTT, 200mM NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:UBE2F
Gene ID:140739
Uniprot ID:UBE2F_HUMAN
Accession Number:NP_542409
Immunogen:Human
Immunogen Region:1-185aa
Immunogen Sequence:MLTLAS KLKRDDGLKG SRTAATASDS TRRVSVRDKL LVKEVAELEA NLPCTCKVHF PDPNKLHCFQ LTVTPDEGYY QGGKFQFETE VPDAYNMVPP KVKCLTKIWH PNITETGEIC LSLLREHSID GTGWAPTRTL KDVVWGLNSL FTDLLNFDDP LNIEAAEHHL RDKEDFRNKV DDYIKRYAR
Tissue Specificity Widely expressed (at protein level).
Post Translational Modifications The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
Function Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex. (Microbial infection) Following infection by HIV-1 virus, participates to HIV-1 Vif protein-mediated ubiquitination and degradation of APOBEC3G by mediating neddylation of cullin-5 (CUL5).
Protein Name Nedd8-Conjugating Enzyme Ube2f
Nedd8 Carrier Protein Ube2f
Nedd8 Protein Ligase Ube2f
Nedd8-Conjugating Enzyme 2
Ring-Type E3 Nedd8 Transferase Ube2f
Ubiquitin-Conjugating Enzyme E2 F
Database Links Reactome: R-HSA-8951664
Reactome: R-HSA-983168
Cellular Localisation
Alternative Protein Names Nedd8-Conjugating Enzyme Ube2f protein
Nedd8 Carrier Protein Ube2f protein
Nedd8 Protein Ligase Ube2f protein
Nedd8-Conjugating Enzyme 2 protein
Ring-Type E3 Nedd8 Transferase Ube2f protein
Ubiquitin-Conjugating Enzyme E2 F protein
UBE2F protein
NCE2 protein

Information sourced from Uniprot.org

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