| Post Translational Modifications | Cleaved by a furin endopeptidase in the trans-Golgi network. |
| Function | Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. |
| Protein Name | Matrix Metalloproteinase-24Mmp-24Membrane-Type Matrix Metalloproteinase 5Mt-Mmp 5Mtmmp5Membrane-Type-5 Matrix MetalloproteinaseMt5-MmpMt5mmp Cleaved Into - Processed Matrix Metalloproteinase-24 |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | Matrix Metalloproteinase-24: Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneRecycled Back To The Plasma Membrane Through The Trans-Golgi Network Via Interaction With Apba3Processed Matrix Metalloproteinase-24: SecretedExtracellular SpaceExtracellular MatrixAlso Shed From Cell Surface As Soluble ProteinaseBy A Proteolytic Cleavage |
| Alternative Protein Names | Matrix Metalloproteinase-24 proteinMmp-24 proteinMembrane-Type Matrix Metalloproteinase 5 proteinMt-Mmp 5 proteinMtmmp5 proteinMembrane-Type-5 Matrix Metalloproteinase proteinMt5-Mmp proteinMt5mmp Cleaved Into - Processed Matrix Metalloproteinase-24 proteinMMP24 proteinMT5MMP protein |
Information sourced from Uniprot.org
