| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.2 Mu m filtered solution of 50mM Tris, 10 mM CaCl2, 150 mM NaCl, pH 7.5. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.01 EU/Mu g by the LAL method. |
| Immunoreactivity: | Recombinant Human MMP-8 Protein cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (RD, Catalog # ES001). The specific activity is >194 pmol/min/µg, as measured under the described conditions. |
| Gene Symbol: | MMP8 |
| Gene ID: | 4317 |
| Uniprot ID: | MMP8_HUMAN |
| Immunogen Region: | Phe21-Gly467 |
| Immunogen: | Recombinant Human MMP-8 Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Phe21-Gly467. |
| Immunogen Sequence: | KCSGPPPPCPPCPPSCHPSL SLQRPALEDLLLGSDASLTC TLNGLRNPEGAVFTWEPSTG KDAVQKKAVQNSCGCYSVSS VLPGCAERWNSGASFKCTVT HPESDTLTGTIAKVTVNTFP PQVHLLPPPSEELALNELVS LTCLVRAFNPKEVLVRWLHG NEELSPESYLVFEPLKEPGE GATTYLVTSVLRVSAELWKQ GDQYSCMVGHEALPMNFTQK TIDRLSGKPTNVSVSVIMS |
| Tissue Specificity | Neutrophils. |
| Function | Can degrade fibrillar type I, II, and III collagens. |
| Protein Name | Neutrophil CollagenaseMatrix Metalloproteinase-8Mmp-8Pmnl CollagenasePmnl-Cl |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasmic GranuleSecretedExtracellular SpaceExtracellular MatrixStored In Intracellular Granules |
| Alternative Protein Names | Neutrophil Collagenase proteinMatrix Metalloproteinase-8 proteinMmp-8 proteinPmnl Collagenase proteinPmnl-Cl proteinMMP8 proteinCLG1 protein |
Information sourced from Uniprot.org