• Human MMP-1 protein (Recombinant) (C-His) (STJP000983)
  • Human MMP-1 protein (Recombinant) (C-His) (STJP000983)
  • Human MMP-1 protein (Recombinant) (C-His) (STJP000983)
  • Human MMP-1 protein (Recombinant) (C-His) (STJP000983)

Human MMP-1 protein (Recombinant) (C-His) (STJP000983)

SKU:
STJP000983

£114.50 - £408.50
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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human MMP-1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured in a cell migration assay using A549 cells.1 ng/mL of Recombinant Human MMP-1 can effectively induce A549 cells migration.2. Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >
Gene Symbol: MMP1
Gene ID: 4312
Uniprot ID: MMP1_HUMAN
Immunogen Region: Phe20-Asn469
Immunogen: Recombinant Human MMP1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe20-Asn469) of human MMP1 (Accession #NP_002412.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase. Tyrosine phosphorylated in platelets by PKDCC/VLK.
Function Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Protein Name Interstitial Collagenase
Fibroblast Collagenase
Matrix Metalloproteinase-1
Mmp-1 Cleaved Into - 22 Kda Interstitial Collagenase - 27 Kda Interstitial Collagenase
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Reactome: R-HSA-1592389
Reactome: R-HSA-210991
Reactome: R-HSA-381426
Reactome: R-HSA-6785807
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Protein Names Interstitial Collagenase protein
Fibroblast Collagenase protein
Matrix Metalloproteinase-1 protein
Mmp-1 Cleaved Into - 22 Kda Interstitial Collagenase - 27 Kda Interstitial Collagenase protein
MMP1 protein
CLG protein

Information sourced from Uniprot.org

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