Human MIB1 protein (Recombinant) (N-His) (STJP005665)

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STJP005665
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MIB1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MIB1
Gene ID: 57534
Uniprot ID: MIB1_HUMAN
Immunogen Region: Arg769-Glu1000
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated.possibly via autoubiquitination. Ubiquitinated.this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
Function E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection.
Protein Name E3 Ubiquitin-Protein Ligase Mib1
Dapk-Interacting Protein 1
Dip-1
Mind Bomb Homolog 1
Ring-Type E3 Ubiquitin Transferase Mib1
Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 2
Database Links Reactome: R-HSA-2122948
Reactome: R-HSA-2644606
Reactome: R-HSA-2691232
Reactome: R-HSA-2894862
Reactome: R-HSA-2979096
Reactome: R-HSA-9013507
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriolar Satellite
Cell Membrane
Localizes To The Plasma Membrane
It Is Mitochondrial
However Such Localization Remains Unclear
Displaced From Centriolar Satellites In Response To Cellular Stress
Such As Ultraviolet Light (Uv) Radiation Or Heat Shock
Alternative Protein Names E3 Ubiquitin-Protein Ligase Mib1 protein
Dapk-Interacting Protein 1 protein
Dip-1 protein
Mind Bomb Homolog 1 protein
Ring-Type E3 Ubiquitin Transferase Mib1 protein
Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 2 protein
MIB1 protein
DIP1 protein
KIAA1323 protein
ZZANK2 protein

Information sourced from Uniprot.org

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