Human Mesothelin/MSLN protein (Recombinant) (C-hFc&Avi) {Biotin} (STJP020194)

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STJP020194-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Biotin
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: MSLN
Gene ID: 10232
Uniprot ID: MSLN_HUMAN
Immunogen Region: Glu296-Gly580
Immunogen: Biotinylated Recombinant Human Mesothelin/MSLN Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Glu296-Gly580) of Human Mesothelin fused with a hFc tag and Avi tag at the C-terminal.
Immunogen Sequence: EVEKTACPSGKKAREIDESL IFYKKWELEACVDAALLATQ MDRVNAIPFTYEQLDVLKHK LDELYPQGYPESVIQHLGYL FLKMSPEDIRKWNVTSLETL KALLEVNKGHEMSPQVATLI DRFVKGRGQLDKDTLDTLTA FYPGYLCSLSPEELSSVPPS SIWAVRPQDLDTCDPRQLDV LYPKARLAFQNMNGSEYFVK IQSFLGGAPTEDLKALSQQN VSMDLATFMKLRTDAVLPL
Tissue Specificity Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Post Translational Modifications Both MPF and the cleaved form of mesothelin are N-glycosylated. Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Function Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Protein Name Mesothelin
Cak1 Antigen
Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor
Mpf - Mesothelin - Cleaved Form
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Megakaryocyte-Potentiating Factor: Secreted
Isoform 3: Secreted
Alternative Protein Names Mesothelin protein
Cak1 Antigen protein
Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor protein
Mpf - Mesothelin - Cleaved Form protein
MSLN protein
MPF protein

Information sourced from Uniprot.org

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Model Name Host Clonality Reactivity Application
STJP001630 Human MSLN/Mesothelin protein (Recombinant) (C-hFc-Avi) {Biotin} (STJP001630) HEK293
STJP001706 Human MSLN/Mesothelin protein (Recombinant) (C-His-Avi) {Biotin} (STJP001706) HEK293
STJP020193 Human Mesothelin/MSLN protein (Recombinant) (C-His&Avi) {Biotin} (STJP020193) HEK293 cells
STJP001231 Human Mesothelin/MSLN protein (Recombinant) (C-hFc&His) (STJP001231) HEK293 cells
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