Human MEPE/OF45 protein (Recombinant-Active) (C-10*His) (STJP012289)

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STJP012289-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human MEPE/OF45-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: MEPE
Gene ID: 56955
Uniprot ID: MEPE_HUMAN
Immunogen Region: Pro18-Asp525
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on serine residues in the ASARM motif (in vitro) by FAM20C.the phosphorylation is important for the inhibition of bone mineralization. Cleaved by CTSB/cathepsin B.the cleavage is blocked by metalloprotease PHEX.
Function Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Promotes dental pulp stem cell proliferation and differentiation.
Protein Name Matrix Extracellular Phosphoglycoprotein
Osteoblast/Osteocyte Factor 45
Of45
Osteoregulin
Database Links Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Protein Names Matrix Extracellular Phosphoglycoprotein
Osteoblast/Osteocyte Factor 45 protein
Of45 protein
Osteoregulin protein
MEPE protein

Information sourced from Uniprot.org

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