Human MEP1B protein (Recombinant-Active) (C-10*His) (STJP012126)

SKU:
STJP012126-100
£503.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Short Description :Recombinant-Active-Human MEP1B-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity:Measured by its ability to cleave a fluorogenic peptide substrate, McaSEVNLDAEFRK (Dpn) RRNH2. The specific activity is >350 pmol/min/µg, as measured under the described conditions.
Gene Symbol:MEP1B
Gene ID:4225
Uniprot ID:MEP1B_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Leu21-Ser593
Post Translational Modifications Phosphorylated by PKC at multiple sites of its cytoplasmic part. Phosphorylation dcreases activity at the cell surface, leading to diminished substrate cleavage. N-glycosylated.contains high mannose and/or complex biantennary structures. O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human. Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues.
Function Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Also cleaves the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides.
Protein Name Meprin A Subunit Beta
Endopeptidase-2
Meprin B
N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta
Paba Peptide Hydrolase
Pph Beta
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Secreted
Homodimers Are Essentially Membrane Bound But May Also Be Shed From The Surface By Adam-10 And Adam-17
Alternative Protein Names Meprin A Subunit Beta protein
Endopeptidase-2 protein
Meprin B protein
N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta protein
Paba Peptide Hydrolase protein
Pph Beta protein
MEP1B protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005521 Human MEP1B protein (Recombinant) (N-His) (STJP005521) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP011804 Human SERPIND1 protein (Recombinant-Active) (C-10*His) (STJP011804) Mammalian Cells ELISA/WB
STJP011852 Human HAPLN1 protein (Recombinant-Active) (C-10*His) (STJP011852) Mammalian Cells ELISA/WB
STJP011956 Human PCSK1 protein (Recombinant-Active) (C-10*His) (STJP011956) Mammalian Cells ELISA/WB
STJP012061 Human CNTN2 protein (Recombinant-Active) (C-10*His) (STJP012061) Mammalian Cells ELISA/WB

Related Products

!