| Post Translational Modifications | Ubiquitinated by TRIM11, leading to proteasomal degradation. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 15Activator-Recruited Cofactor 105 Kda ComponentArc105Ctg Repeat Protein 7aMediator Complex Subunit 15Positive Cofactor 2 Glutamine/Q-Rich-Associated ProteinPc2 Glutamine/Q-Rich-Associated ProteinTpa-Inducible Gene 1 ProteinTig-1Trinucleotide Repeat-Containing Gene 7 Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Mediator Of Rna Polymerase Ii Transcription Subunit 15 proteinActivator-Recruited Cofactor 105 Kda Component proteinArc105 proteinCtg Repeat Protein 7a proteinMediator Complex Subunit 15 proteinPositive Cofactor 2 Glutamine/Q-Rich-Associated Protein proteinPc2 Glutamine/Q-Rich-Associated Protein proteinTpa-Inducible Gene 1 Protein proteinTig-1 proteinTrinucleotide Repeat-Containing Gene 7 Protein proteinMED15 proteinARC105 proteinCTG7A proteinPCQAP proteinTIG1 proteinTNRC7 protein |
Information sourced from Uniprot.org
