Human MEF2C protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007380)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MEF2C-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MEF2C |
| Gene ID | 4208 |
| Uniprot ID | MEF2C_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg10-Gly95 |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-59 enhances DNA binding activity. Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation. Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity. Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation. |
| Function | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1. |
| Protein Name | Myocyte-Specific Enhancer Factor 2cMyocyte Enhancer Factor 2c |
| Database Links | Reactome: R-HSA-198753Reactome: R-HSA-2151201Reactome: R-HSA-400253Reactome: R-HSA-525793Reactome: R-HSA-9022707Reactome: R-HSA-9707616Reactome: R-HSA-9733709 |
| Cellular Localisation | NucleusCytoplasmSarcoplasm |
| Alternative Protein Names | Myocyte-Specific Enhancer Factor 2c proteinMyocyte Enhancer Factor 2c proteinMEF2C protein |
Information sourced from Uniprot.org