Human MBD3 protein (Recombinant) (His-Tag) (STJP017855)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MBD3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 1mM DTT, 1mM EDTA |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MBD3 |
| Gene ID | 53615 |
| Uniprot ID | MBD3_HUMAN |
| Accession Number | NP_003917 |
| Immunogen | Human |
| Immunogen Region | 1-291aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMERKRWE CPALPQGWER EEVPRRSGLS AGHRDVFYYS PSGKKFRSKP QLARYLGGSM DLSTFDFRTG KMLMSKMNKS RQRVRYDSSN QVKGKPDLNT ALPVRQTASI FKQPVTKITN HPSNKVKSDP QKAVDQPRQL FWEKKLSGLN AFDIAEELVK TMDLPKGLQG VGPGCTDETL LSAIASALHT STMPITGQLS AAVEKNPG |
Additional Info
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to methylated DNA by itself. Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 3Methyl-Cpg-Binding Protein Mbd3 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosomeNuclearIn Discrete FociDetected On ChromatinAt Promoter Regions Of Active Genes |
| Alternative Protein Names | Methyl-Cpg-Binding Domain Protein 3 proteinMethyl-Cpg-Binding Protein Mbd3 proteinMBD3 protein |
Information sourced from Uniprot.org