Human Low-density lipoprotein receptor/LDLR protein (Recombinant) (C-His) (STJP002585)

SKU:
STJP002585

£123.50 - £274.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human LDLR at 5 Mu g/mL (100 Mu L/well) can bind Human PCSK9 with a linear range of 0.5-294.7ng/mL.
Gene Symbol: LDLR
Gene ID: 3949
Uniprot ID: LDLR_HUMAN
Immunogen Region: Ala22-Arg788
Immunogen: Recombinant Human Low-density lipoprotein receptor/LDLR Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Arg788) of human LDLR/LDL Receptor (Accession #NP_000518.1) fused with a 6×His tag at
Immunogen Sequence: AVGDRCERNEFQCQDGKCIS YKWVCDGSAECQDGSDESQE TCLSVTCKSGDFSCGGRVNR CIPQFWRCDGQVDCDNGSDE QGCPPKTCSQDEFRCHDGKC ISRQFVCDSDRDCLDGSDEA SCPVLTCGPASFQCNSSTCI PQLWACDNDPDCEDGSDEWP QRCRGLYVFQGDSSPCSAFE FHCLSGECIHSSWRCDGGPD CKDKSDEENCAVATCRPDEF QCSDGNCIHGSRQCDREYD
Function Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus.
Protein Name Low-Density Lipoprotein Receptor
Ldl Receptor
Database Links Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-8964026
Reactome: R-HSA-8964038
Reactome: R-HSA-975634
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane
Clathrin-Coated Pit
Golgi Apparatus
Early Endosome
Late Endosome
Lysosome
Rapidly Endocytosed Upon Ligand Binding
Localized At Cell Membrane
Probably In Lipid Rafts
In Serum-Starved Conditions
Alternative Protein Names Low-Density Lipoprotein Receptor protein
Ldl Receptor protein
LDLR protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance