This LNPEP Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids..
Applications
ELISA
Reactivity
Human
Sensitivity
0.58ng/mL
Detection Limit
1.56-100ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
serum, plasma, tissue homogenates or other biological fluids.
Additional Info
Tissue Specificity
Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
Post Translational Modifications
The pregnancy serum form is derived from the membrane-bound form by proteolytic processing. N-glycosylated.
Function
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Protein Name
Leucyl-Cystinyl AminopeptidaseCystinyl AminopeptidaseInsulin-Regulated Membrane AminopeptidaseInsulin-Responsive AminopeptidaseIrapOxytocinaseOtasePlacental Leucine AminopeptidaseP-Lap Cleaved Into - Leucyl-Cystinyl Aminopeptidase - Pregnancy Serum Form
Cell MembraneSingle-Pass Type Ii Membrane ProteinIn Brain Only The Membrane-Bound Form Is FoundThe Protein Resides In Intracellular Vesicles Together With Glut4 And Can Then Translocate To The Cell Surface In Response To Insulin And/Or OxytocinLocalization May Be Determined By Dileucine Internalization MotifsAnd/Or By Interaction With TankyrasesLeucyl-Cystinyl AminopeptidasePregnancy Serum Form: SecretedDuring Pregnancy Serum Levels Are Low In The First TrimesterRise Progressively During The Second And Third Trimester And Decrease Rapidly After Parturition
