Human LNPEP (Leucyl/Cystinyl Aminopeptidase) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016761)
SPECIFICATIONS
General Information
| Short Description | This LNPEP Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.58ng/mL |
| Detection Limit | 1.56-100ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | LNPEP |
| Gene ID | 4012 |
| Uniprot ID | LCAP_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. |
| Post Translational Modifications | The pregnancy serum form is derived from the membrane-bound form by proteolytic processing. N-glycosylated. |
| Function | Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. |
| Protein Name | Leucyl-Cystinyl AminopeptidaseCystinyl AminopeptidaseInsulin-Regulated Membrane AminopeptidaseInsulin-Responsive AminopeptidaseIrapOxytocinaseOtasePlacental Leucine AminopeptidaseP-Lap Cleaved Into - Leucyl-Cystinyl Aminopeptidase - Pregnancy Serum Form |
| Database Links | Reactome: R-HSA-1236977Reactome: R-HSA-1445148Reactome: R-HSA-983168 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIn Brain Only The Membrane-Bound Form Is FoundThe Protein Resides In Intracellular Vesicles Together With Glut4 And Can Then Translocate To The Cell Surface In Response To Insulin And/Or OxytocinLocalization May Be Determined By Dileucine Internalization MotifsAnd/Or By Interaction With TankyrasesLeucyl-Cystinyl AminopeptidasePregnancy Serum Form: SecretedDuring Pregnancy Serum Levels Are Low In The First TrimesterRise Progressively During The Second And Third Trimester And Decrease Rapidly After Parturition |
| Alternative ELISA Names | Leucyl-Cystinyl Aminopeptidase ELISA kitCystinyl Aminopeptidase ELISA kitInsulin-Regulated Membrane Aminopeptidase ELISA kitInsulin-Responsive Aminopeptidase ELISA kitIrap ELISA kitOxytocinase ELISA kitOtase ELISA kitPlacental Leucine Aminopeptidase ELISA kitP-Lap Cleaved Into - Leucyl-Cystinyl Aminopeptidase - Pregnancy Serum Form ELISA kitLNPEP ELISA kitOTASE ELISA kit |
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Information sourced from Uniprot.org