Human LINGO1 protein (Recombinant) (C-His) (STJP007125)

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STJP007125
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LINGO1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LINGO1
Gene ID: 84894
Uniprot ID: LIGO1_HUMAN
Immunogen Region: Cys42-Pro549
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Contains predominantly high-mannose glycans.
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Protein Name Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1
Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1
Leucine-Rich Repeat Neuronal Protein 1
Leucine-Rich Repeat Neuronal Protein 6a
Database Links Reactome: R-HSA-193634
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 protein
Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1 protein
Leucine-Rich Repeat Neuronal Protein 1 protein
Leucine-Rich Repeat Neuronal Protein 6a protein
LINGO1 protein
LERN1 protein
LRRN6A protein
UNQ201 protein
PRO227 protein

Information sourced from Uniprot.org

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