Tissue Specificity | Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung. |
Post Translational Modifications | N-glycosylation is required for ligand binding. |
Function | Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. |
Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3Cd85 Antigen-Like Family Member EImmunoglobulin-Like Transcript 6Ilt-6Leukocyte Immunoglobulin-Like Receptor 4Lir-4Monocyte Inhibitory Receptor Hm43/Hm31Cd Antigen Cd85e |
Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
Cellular Localisation | Secreted |
Alternative ELISA Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 ELISA kitCd85 Antigen-Like Family Member E ELISA kitImmunoglobulin-Like Transcript 6 ELISA kitIlt-6 ELISA kitLeukocyte Immunoglobulin-Like Receptor 4 ELISA kitLir-4 ELISA kitMonocyte Inhibitory Receptor Hm43/Hm31 ELISA kitCd Antigen Cd85e ELISA kitLILRA3 ELISA kitILT6 ELISA kitLIR4 ELISA kit |
output | |
Information sourced from Uniprot.org