Human LILRA3/CD85e protein (Recombinant) (hIgG-His-Tag) (STJP019567)

Name: Human LILRA3/CD85e protein (Recombinant) (hIgG-His-Tag) (STJP019567)
SKU: STJP019567
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostHEK293 Cells

ImmunogenHuman

STJP019567

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Short Description	Recombinant-Human LILRA3/CD85e-hIgG-His-Tag protein was developed from hek293 cells and has a target region of hIgG-His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	HEK293 Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)

Gene Symbol	LILRA3
Gene ID	11026
Uniprot ID	LIRA3_HUMAN
Accession Number	NP_006856.3
Immunogen	Human
Immunogen Region	24-439aa
Immunogen Sequence	GPLPKPT LWAEPGSVIT QGSPVTLRCQ GSLETQEYHL YREKKTALWI TRIPQELVKK GQFPILSITW EHAGRYCCIY GSHTAGLSES SDPLELVVTG AYSKPTLSAL PSPVVTSGGN VTIQCDSQVA FDGFILCKEG EDEHPQCLNS HSHARGSSRA IFSVGPVSPS RRWSYRCYGY DSRAPYVWSL PSDLLGLLVP GVSKKPSLSV QPGPVVAPGE KLTFQC

Tissue Specificity	Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
Post Translational Modifications	N-glycosylation is required for ligand binding.
Function	Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Protein Name	Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 Cd85 Antigen-Like Family Member E Immunoglobulin-Like Transcript 6 Ilt-6 Leukocyte Immunoglobulin-Like Receptor 4 Lir-4 Monocyte Inhibitory Receptor Hm43/Hm31 Cd Antigen Cd85e
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-6798695
Cellular Localisation	Secreted
Alternative Protein Names	Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 protein Cd85 Antigen-Like Family Member E protein Immunoglobulin-Like Transcript 6 protein Ilt-6 protein Leukocyte Immunoglobulin-Like Receptor 4 protein Lir-4 protein Monocyte Inhibitory Receptor Hm43/Hm31 protein Cd Antigen Cd85e protein LILRA3 protein ILT6 protein LIR4 protein

Information sourced from Uniprot.org