Human LGMN protein (Recombinant) (N-His) (STJP005888)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LGMN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LGMN |
| Gene ID | 5641 |
| Uniprot ID | LGMN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro19-His432 |
Additional Info
| Post Translational Modifications | Activated by autocatalytic processing at pH 4. |
| Function | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. |
| Protein Name | LegumainAsparaginyl EndopeptidaseAepProtease - Cysteine 1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-196791Reactome: R-HSA-2132295 |
| Cellular Localisation | Lysosome |
| Alternative Protein Names | Legumain proteinAsparaginyl Endopeptidase proteinAep proteinProtease - Cysteine 1 proteinLGMN proteinPRSC1 protein |
Information sourced from Uniprot.org