| Post Translational Modifications | Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components. |
| Function | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses. |
| Protein Name | Lymphocyte Cytosolic Protein 2Sh2 Domain-Containing Leukocyte Protein Of 76 KdaSlp-76 Tyrosine PhosphoproteinSlp76 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202433Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Lymphocyte Cytosolic Protein 2 proteinSh2 Domain-Containing Leukocyte Protein Of 76 Kda proteinSlp-76 Tyrosine PhosphoproteinSlp76 proteinLCP2 protein |
Information sourced from Uniprot.org
